Limited evidence

3 facts graded limited. Early or small human studies. Interesting, not settled.

CBD for anxiety: promising, early, and probably dose-dependentSmall human trials show CBD reducing experimentally induced anxiety (e.g., simulated public speaking), but large definitive trials are missing, and effective doses in studies (300–600mg) dwarf most retail products (10–25mg). The molecule is interesting; the average gummy is underdosed.Limited
THCV: the cannabinoid that can block the munchiesTetrahydrocannabivarin (THCV) acts as a CB1 antagonist at low doses — the opposite move of THC — and early human studies explore it for appetite control and blood-sugar regulation. Effects flip at higher doses where it can activate CB1. Fascinating pharmacology, thin human data.Limited
Limonene may take the edge off THC-induced anxiety — first human dataA 2024 Johns Hopkins double-blind trial gave participants THC with vaporized limonene: anxiety and paranoia ratings dropped meaningfully at higher limonene doses. One small trial is not a prescription, but it is the first controlled human evidence for an entourage-style interaction.Limited